Team discovers transient rise in depletion attraction contributes to mitotic chromosome condensation
(A) Histone staining images and OI-DIC density imaging of human living cells in the interphase (the phase between cell divisions, left) and mitotic phase (right). The bottom two rows are OI-DIC ...
This process makes the chromosomes rigid to resist the pulling force from the spindle. While several proteins involved in the condensation process, including condensins and topoisomerase IIα, have ...
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